UCSF
Molecular Design Institute
News
2001-02.
1999
.
1998 . 1997 . 1996
Current
News
1996
UCSF
Faculty Research Lectureship
Irwin
D. Kuntz, Ph.D.
Professor of Chemistry and
Pharmaceutical Chemistry
Adjunct Professor, Biochemistry
and Biophysics
Director, Molecular Design
Institute
This figure depicts a new method of structure-based
drug design pioneered at UCSF to produce a DNA binding agent. The yellow
is a small computer designed molecule which has been found to bind to DNA
(represented by a segment showing blue adenine-thymine based pairs and
red phosphate groups). Such binding agents have potential therapeutic value
for gene-based cures.
The Faculty Research Lectureship
represents the foremost recognition of scientific achievement bestowed
on a member of the faculty of UCSF.
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1997
UCSF
Daybreak
September
5, 1997
Thomas
Scanlan, Associate Professor Pharmaceutical Chemistry at UCSF,
and Peter Kushner, Associate Research Biochemist with UCSF's Metabolic
Research Institute, report in this date's issue of Science that when
estrogen or certain drugs act through estroben receptor beta, the response
of cells may be quite different than with the better know estrogen receptor,
now renamed estrogen receptor alpha.
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1998
UCSF
Daybreak
March
12, 1998
Tom
Ferrin, director of the UCSF Computer Graphics Laboratory, was
one of 18 university, government and industry scientists demonstrating
the power and potential of the Internet to members of Congress, other policy
makers and national media today in Washington, DC. Ferrin and co-investigators
in the department of pharmaceutical chemistry have developed a prototype
"collaboratory"
that will allow scientists from around the country to share and interactively
manipulate three-dimensional molecular models for applications such as
drug and biomaterials design and protein engineering.
NPR
Science Friday
October
23, 1998
In
a segment of the popular Friday radio program produced by Karin Vergoth,
guests Peter Kollman
from UCSF, Lynne Regan from Yale University, and Fred
Cohen from UCSF discussed the recent paper "Pathways
to a protein folding intermediate observed in a one microsecond simulation
in aqueous solution" by Yong Duan and Peter Kollman in Science,
23 October 1998, p 740 and challenges in modeling protein folding.
UCSF
Daybreak
December
28, 1998
Results
of studies, published in the December 23 issue of Cell, provide valuable
clues about ways to design new, more effective disease-preventing medications
with fewer side effects based on the molecular mechanism by which tamoxifen
blocks the effects of estrogen. This process has been shown to prevent
breast cancer in some women at high risk. David
Agard, Professor Biochemistry and Biophysics and Howard Hughes
Medial Investigator at UCSF is a senior author of the paper.
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1999
Chemical
& Engineering News
March 22, 1999
This
C&E News report highlights the use of protoporphyrin molecules as scaffolds
on which to attach carboranyl cages, as in the decacarboranyl diglucosyl
porphyrin from the laboratory of Steve
Kahl
at UCSF. In this work, two glycosyl groups attached
to the protoporphyrin carry 10 carboranyl cages, or 100 boron atoms. In
the space-filling model, the boron atoms are red, carbon atoms are dark
blue, the porphyrin ring nitrogen atoms are light blue, and oxygen atoms
are yellow.
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2001
UCSF
Memorial for Professor Peter Kollman
July 6, 2001
The UCSF Memorial Service for Professor
Peter
Kollman, who passed away May 25 after a brief battle with cancer (DayBreak:
Campus
Loses a Leading Scientist and Friend), was held on July 6, 2001, at
3:00 PM in Cole Hall at the Parnassus Campus of the University of California
San Francisco. Many friends and colleagues of Professor Kollman attended
filling Cole Hall. The memorial service was followed by a reception
in the Millbury Union.
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2002
UCSF
/ Biophysical Society Symposium Honoring Peter A. Kollman
February 21-22,
2002
On February 21-22,
2002, scientists from academia and industry met in San Francisco
to honor the memory of Peter
Kollman and to discuss molecular simulations in structural biology
and drug discovery. Organized by Professors Ken
Dill, Thomas Cheatham,
and Kennie Merz, the symposium
brought together three hundred participants at the University of California
San Francisco. Professor Kollman, whose work profoundly influenced computational
chemistry, structural biology and drug discovery, was Professor of Chemistry
and Pharmaceutical Chemistry at UCSF from 1971 to 2001. The meeting was
sponsored by the UCSF
Department
of Pharmaceutical Chemistry and the UCSF Molecular
Design Institute. It was co-sponsored by the Biophysical
Society as a satellite meeting of the Year 2002 Annual Biophysical
Society Meeting.
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