UCSF/MDI
Symposium
University of
California San Francisco
Department
of Pharmaceutical Chemistry and Molecular
Design Institute
Symposium
"Drug
Design and Discovery"
October
13-14, 2000
Go
to: Meeting Overview
Speakers and Program:
Johan
Aqvist,
Uppsala
University
Paul Anderson,
Dupont
Pharmaceuticals
Ken
Dill, University of California San Francisco
David Diller,
Pharmacopeia
Robert
Fletterick, University of California San Francisco
Simon Kearsley,
Merck
Research Laboratories
Peter
Kollman,
University
of California San Francisco
Irwin
Kuntz, University
of California San Francisco
Robert McDowell,
Sunesis
Jon Mason, Bristol
Myers Squibb
David Pearlman,
Vertex
Pharmaceuticals
Tom
Scanlan, University of California San Francisco
Bruce
Tidor,
Massachusetts
Institute of Technology
Dennis Underwood,
DuPont
Pharmaceuticals
Gennady Verkhivker,
Agouron
Pharmaceuticals
October
13, 2000
| 7:30
- 8:50 |
Registration and Continental Breakfast |
| 8:50
- 9:00 |
Welcome:
Mary Anne Koda-Kimble, Dean
School of Pharmacy, and Peter Kollman |
| 9:00
- 10:00 |
Keynote Address : Paul
Anderson"Drug Discovery in the Pharmaceutical Industry" |
| 10:00-10:30 |
Break |
| 10:30-11:15 |
Irwin Kuntz "Design
of Combinatorial Libraries" |
| 11:15-12:00 |
David Pearlman"New
Methods for Predicting Molecular Binding and Database Screening" |
| 12:00-1:00 |
Lunch |
| 1:00
- 1:45 |
Jonathan Mason
"Virtual
Screening Applications in the Drug Discovery Process" |
| 1:45
- 2:30 |
David
Diller "Pharmaconomics: The Storage and Mining of Structural
and Biological Information Regarding Pharmaceutically Relevant Molecules" |
| 2:30
- 3:15 |
Johan Aqvist"Ligand
Binding Affinity Prediction from MD Simulations" |
| 3:15
- 3:45 |
Break |
| 3:45
- 4:30 |
Bruce Tidor "Solvation
Effects on Protein Folding, Binding and Design: Exploring the Electrostatic
Balance" |
| 4:30-5:15 |
Dennis
Underwood
"Ligand Promiscuity in GPCRs" |
| 5:15
- 6:30 |
Poster Session |
| 7:00
- 8:00 |
Dinner |
October
14, 2000
| 8:00
- 9:00 |
Continental Breakfast |
| 9:00
- 9:45 |
Ken Dill
"Combining Traveling Salesmen with Protein Folding to Get a Fast Conformational
Search Strategy |
| 9:45
- 10:30 |
Gennady Verkhivker
"Hierarchical Simulation Models in Predicting Molecular Recognition Mechanisms
from Binding Free Energy Landscapes" |
| 10:30-11:00 |
Break |
| 11:00-11:45 |
Simon Kearsley
"Beyond
Chemical Database Mining" |
| 11:45-12:30 |
Robert McDowell
"Adaptivity
and Ligand Binding: IL-2" |
| 12:30-2:00 |
Lunch and Poster Session |
| 2:00-2:45 |
Robert
Fletterick "Activation of Nuclear Receptors" |
| 2:45-3:30 |
Thomas Scanlan
"Discovery
and Design of Selective Thyro-Mimetics" |
| 3:30
- 4:00 |
Break |
| 4:00
- 4:45 |
Peter Kollman
"New Theoretical Methods in Structure Based Design" |
| 4:45 - 5:00 |
Concluding Remarks |
Go
to: Meeting Overview
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